On first use, prime the spray by briefly pressing the nozzle. From the onset of colds and sinusitis: Keeping the head straight, put the nozzle in the nostril. Spray once or twice in each nostril. Let any excess solution flow out and then blow your nose. For a deeper cleansing of the nasal cavities and blocked noses: Keeping the head tilted to one side, put the nozzle in the upper nostril. Spray once for 2 to 3 seconds. Let any excess solution flow out and then blow your nose. After each use, clean the nozzle in hot, soapy water, then rinse and dry with a clean and soft cloth. Use 2 to 6 times a day for as long as needed or as long as your doctor recommends.